Bradykinins Function by Which of the Following Mechanisms

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Bradykinin is a physiologically and pharmacologically. Bradykinin plays a prominent role in inflammation.


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Bradykinin is inactivated by angiotensin-converting enzyme ACE in the lungs and kidneys 3.

. It causes arterioles to dilate via the release of prostacyclin nitric oxide and endothelium-derived hyperpolarizing factor and makes veins constrict via prostaglandin F2 thereby leading to leakage into capillary beds due to the increased pressure in the capillaries. Bradykinin plays a prominent role in inflammation. Bradykinin BK has multiple pathophysiologic functions such as induction of vascular permeability and mitogenesis and it triggers the release of other mediators such as nitric oxide in inflammatory and cancer tissues 4.

Bradykinin along with prostaglandins and histamine are mediators of vasodilation in which the arteriolar smooth muscle relaxes and in turn increases blood flow. Bradykinin a biologically active peptide is released by the breakdown of a high molecular weight kininogen by kallikreins Altamura et al 1999. Bradykinin is a peptide that promotes inflammation.

Bradykinin along with prostaglandins and histamine are mediators of vasodilation in which the arteriolar smooth muscle relaxes and in turn increases blood flow. Bradykinin BK is a potent short-lived effector belonging to a class of peptides known as kinins. Bradykinin works by being a vasodilator which means that it causes the smooth muscle cells that are inside the blood vessel walls to relax.

BK exerts its biological effects through the activation of the bradykinin B2 receptor BKB2R which is G-protein-coupled and is. Bradykinin is involved in plasma extravasation bronchoconstriction nociception vasodilation and inflammation Burch et al 1990. When this relaxation phenomenon happens the blood.

This increased blood flow causes the rubor or redness and calor or warmth components of the inflammation process. It mediates inflammation by causing vasodilation by increasing vascular permeability and by stimulating. It participates in inflammatory and vascular regulation and processes including angioedema tissue permeability vascular dilation and smooth muscle contraction.


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